Corrigendum to: “Plasma concentration of the neurofilament light protein (NFL) is a biomarker of CNS injury in HIV infection: A cross-sectional study” [EBioMedicine 3 (216) 135–140]
نویسندگان
چکیده
HIV negative (HIV-neg) 19 9.3 (5.9–13.1) 363 (264–487) Primary HIV infection (PHI) 13 11.2 (8.2–16.6) 732 (456–1288) Neuroasymtpomatic HIV (NA) CD4 N 350 19 9.0 (6.5–14.3) 488 (374–694) CD4 200–349 17 9.7 (7.6–12.2) 573 (464–764) CD4 50–199 19 12.1 (7.8–44.7) 640 (490–1530) CD4 b 50 20 39.6 (12.0–103) 2415 (690–4420) HIV-associated dementia (HAD) 11 114 (46.0–235) 16,185 (1513–43,010) HIV, treated-suppressed (ART) 22 11.1 (8.6–12.8) 582 (322–706)
منابع مشابه
Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study
BACKGROUND Cerebrospinal fluid (CSF) neurofilament light chain protein (NFL) is a sensitive marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS dysfunction injury that is common in untreated HIV infection. However, an important limitation is the requirement for lumbar puncture. For this reason, a sensitive and reliable blood biomarker of CNS injury would re...
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BACKGROUND Prevalence of neurocognitive impairment in HIV-1 infected patients is reported to be high. Whether this is a result of active HIV-related neurodegeneration is unclear. We examined axonal injury in HIV-1 patients by measuring the light subunit of neurofilament protein (NFL) in CSF with a novel, sensitive method. METHODS With a cross-sectional design, CSF concentrations of neurofilam...
متن کاملCerebrospinal fluid signs of neuronal damage after antiretroviral treatment interruption in HIV-1 infection
BACKGROUND The neurofilament is a major structural component of myelinated axons. Increased cerebrospinal fluid (CSF) concentrations of the light chain of the neurofilament protein (NFL) can serve as a sensitive indicator of central nervous system (CNS) injury. To assess whether interrupting antiretroviral treatment of HIV infection might have a deleterious effect on the CNS, we measured NFL le...
متن کاملCerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection
The character of central nervous system (CNS) HIV infection and its effects on neuronal integrity vary with evolving systemic infection. Using a cross-sectional design and archived samples, we compared concentrations of cerebrospinal fluid (CSF) neuronal biomarkers in 143 samples from 8 HIV-infected subject groups representing a spectrum of untreated systemic HIV progression and viral suppressi...
متن کاملAssociation between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection
OBJECTIVE To investigate the role of homocysteine in neuronal injury in HIV infection. METHODS Using a cross-sectional design and archived samples, we compared concentrations of plasma homocysteine and cerebrospinal fluid (CSF) neurofilament light protein (NFL), a sensitive marker of neuronal injury, in 83 HIV-1-infected subjects without antiretroviral treatment. We also analyzed plasma vitam...
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